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Microb Pathog. 1995 Jun;18(6):387-99.

Plasmid coding for drug resistance and invasion of epithelial cells in enteropathogenic Escherichia coli 0111:H.

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Department of Microbiology, Immunology and Parasitology, Escola Paulista de Medicina, São Paulo, Brazil.


Enteropathogenic Escherichia coli (EPEC) can adhere to, invade and multiply in human epithelial cells. To define the elements required for bacterial invasion, we isolated from an 0111:H- EPEC a 6.6 kb plasmid that is capable of conferring to an avirulent, non-adherent E. coli K12 strain (DK1) the capacity to invade epithelial cells. With this system a dissociation was possible between bacterial invasion and adherence to epithelial cells. Bacteria containing this plasmid synthesise a protein of 32 kDa (pl 4.93) which seemed to be required for cell invasion. The results provide a new basis for strategies to prevent EPEC infections.

[Indexed for MEDLINE]

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