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J Pediatr. 1996 Jan;128(1):141-6.

Treatment of hemangiomas of infants with high doses of prednisone.

Author information

1
Department of Pediatrics, Meir General Hospital, Sapir Medical Center, Kfar Saba, Israel.

Abstract

OBJECTIVE:

We reviewed our experience with the use of oral corticosteroid therapy in treating hemangiomas of infants to determine the optimal effective dose.

STUDY DESIGN:

During a 24-year period, 60 infants with hemangiomas were treated with an initial dose of either 3 or 5 mg/kg per day of orally administered prednisone for a period ranging from 6 to 12 weeks. Involution of the hemangioma and re-growth. were monitored.

RESULTS:

Overall, excellent and rapid results were achieved in 68% of infants and good results occurred in 25%. In 7% treatment was deemed to have failed. Forty-seven of 60 patients received one course of therapy, 8 received 2 courses, and 5 required 3 courses. An initial dose of 5 mg/kg per day oral prednisone therapy was more effective than 3 mg/kg per day. Side effects were not serious and resolved after discontinuation of therapy.

CONCLUSIONS:

High oral doses of corticosteroids (5 mg/kg per day prednisone) provide an effective, rapid, and safe modality of treatment of hemangiomas of infants. We recommend that treatment continue for 6 to 8 weeks, and in more severe cases for as long as 12 weeks.

PMID:
8551406
DOI:
10.1016/s0022-3476(96)70446-8
[Indexed for MEDLINE]

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