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Lancet. 1996 Jan 20;347(8995):159-60.

Association of apolipoprotein E epsilon 4 allele with bulbar-onset motor neuron disease.

Author information

1
King's MND Care and Research Centre, London, UK.

Abstract

BACKGROUND:

Variants of the apolipoprotein E (APOE) gene influence the age of onset of Alzheimer's disease. APOE may influence the presentation of other neurological diseases. We investigated the relationship between the allelic variants of apolipoprotein E and clinical presentation in motor neuron disease.

METHODS:

123 patients with motor neuron disease and 121 controls were studied. Diagnosis, location of onset and date of onset were recorded prospectively. Genotyping was performed blind to clinical information.

FINDINGS:

Possession of at least one epsilon 4 allele was significantly more common in patients with bulbar onset motor neuron disease (14/33, 42%) than in limb onset patients (20/90, 22%) and controls (26/121, 21%) (chi 2 = 4.93, p = 0.026 and chi 2 = 5.91, p = 0.015, respectively).

INTERPRETATION:

These results suggest that the apolipoprotein E epsilon 4 allele may influence the pattern of motor neuron loss in motor neuron disease and that it may affect neuronal function in ways unrelated to the deposition of beta-amyloid or accumulation of neurofibrillary tangles.

PMID:
8544551
DOI:
10.1016/s0140-6736(96)90343-8
[Indexed for MEDLINE]

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