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Hum Mol Genet. 1995 Sep;4(9):1625-8.

Familial non-specific dementia maps to chromosome 3.

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Department of Biochemistry and Molecular Genetics, St Mary's Hospital Medical School, London, UK.


A significant minority of degenerative dementias lack distinctive inclusion bodies, plagues or tangles on pathological examination. Half of these cases have a positive family history of dementia. We have studied the largest published family with such a dementia and mapped the disease locus to a 12 cM region of chromosome 3 spanning the centromere. Haplotype analysis demonstrates a common region shared between all affected individuals between the markers D3S1284 and D3S1603. Like a number of other late onset neurodegenerative diseases, the disease presents at an earlier age when paternally inherited.

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