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Neuroreport. 1995 Sep 11;6(13):1761-5.

A calcium-permeable cGMP-activated cation conductance in hippocampal neurons.

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Section of Neurobiology, Yale University School of Medicine, New Haven, CT 06510, USA.
Yale U, New Haven, CT


Whole-cell patch clamp recordings detected a previously unidentified cGMP-activated membrane conductance in cultured rat hippocampal neurons. This conductance is nonselectively permeable for cations and is completely but reversibly blocked by external Cd2+. The Ca2+ permeability of the hippocampal cGMP-activated conductance was examined in detail, indicating that the underlying ion channels display a high relative permeability for Ca2+. The results indicate that hippocampal neurons contain a cGMP-activated membrane conductance that has some properties similar to the cyclic nucleotide-gated channels previously shown in sensory receptor cells and retinal neurons. In hippocampal neurons this conductance similarly could mediate membrane depolarization and Ca2+ fluxes in response to intracellular cGMP elevation.

[Indexed for MEDLINE]

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