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Zh Vyssh Nerv Deiat Im I P Pavlova. 1995 Jul-Aug;45(4):765-74.

[A comparative analysis of the complex realization of the goal-directed behavior of animals under chronic morphine and cocaine administration].

[Article in Russian]


A new approach to estimation and prediction of morphine and cocaine effects was proposed based on the analysis of animal behaviour directed to a satisfaction of one of the main biological needs, thirst. Both morphine and cocaine did not essentially effect the level of the basic biological (drinking) motivation by the index of the general volume of liquid consumption. Both drugs produced opposite effects on the duration of recognition/manipulation and drinking components of the structure of water-reinforced instrumental act. The proposed methodology is of diagnostic and prognostic value in respect of the complex behavioural effects of the drugs and presumably some other active factors.

[Indexed for MEDLINE]

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