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Nature. 1996 Jan 18;379(6562):225-32.

Structure and mechanism of DNA topoisomerase II.

Author information

1
Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA.

Erratum in

  • Nature 1996 Mar 14;380(6570):179.

Abstract

The crystal structure of a large fragment of yeast type II DNA topoisomerase reveals a heart-shaped dimeric protein with a large central hole. It provides a molecular model of the enzyme as an ATP-modulated clamp with two sets of jaws at opposite ends, connected by multiple joints. An enzyme with bound DNA can admit a second DNA duplex through one set of jaws, transport it through the cleaved first duplex, and expel it through the other set of jaws.

PMID:
8538787
DOI:
10.1038/379225a0
[Indexed for MEDLINE]

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