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Nature. 1996 Jan 11;379(6561):131-7.

Requirement for Xist in X chromosome inactivation.

Author information

1
Section of Comparative Biology, Royal Postgraduate Medical School, Hammersmith Hospital, London, UK.

Abstract

The Xist gene has been proposed as a candidate for the X inactivation centre, the master regulatory switch locus that controls X chromosome inactivation. So far this hypothesis has been supported solely by indirect evidence. Here we describe gene targeting of Xist, and provide evidence for its absolute requirement in the process of X chromosome inactivation.

PMID:
8538762
DOI:
10.1038/379131a0
[Indexed for MEDLINE]

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