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J Infect Dis. 1996 Jan;173(1):265-8.

Evidence for genetic regulation of susceptibility to toxoplasmic encephalitis in AIDS patients.

Author information

1
Department of Immunology and Infectious Diseases, Palo Alto Medical Foundation, CA 94301, USA.

Abstract

The frequency of HLA-DQ antigens in AIDS patients with toxoplasmic encephalitis (TE) were examined. HLA-DQ3 was significantly more frequent in white North American AIDS patients with TE (85.0%) than in the general white population (51.8%; P = .007, corrected P = .028) or randomly selected control AIDS patients who had not developed TE (40.0%; P = .016). In contrast, the frequency of HLA-DQ1 was lower in TE patients than in healthy controls (40.0% vs. 66.5%, P = .027), but this difference did not reach statistical significance when corrected for the number of variables tested (corrected P = .108 for the general white population). HLA-DQ3 thus appears to be a genetic marker of susceptibility to development of TE in AIDS patients, and DQ1 may be a resistance marker. These HLA associations with disease indicate that development of TE in AIDS patients is affected by a gene or genes in the HLA complex and that HLA-DQ typing may help in decisions regarding TE prophylaxis.

PMID:
8537674
DOI:
10.1093/infdis/173.1.265
[Indexed for MEDLINE]

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