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Brain Res. 1995 Sep 4;690(2):259-63.

GBR-12909-induced self-injurious behavior: role of dopamine.

Author information

1
Department of Pharmacology and Toxicology, Northwest Center for Medical Education, Indiana University School of Medicine, Gary 46408, USA.

Abstract

A regimen of repeated administration of GBR (10 or 20 mg/kg/day, i.p., for 4 days) to female Sprague-Dawley rats induced a dose-and time-related increase in the incidence of self-injurious behavior (SIB) that consisted of injury to body areas, paws and tail. The treatment regimen decreased striatal DA and DOPAC levels. Dopaminergic denervation with 6-hydroxydopamine (6-OHDA) or D1 DA antagonist, SCH-23390 or D2 DA antagonist, spiperone, blocked the GBR-induced SIB. Male rats were less sensitive than female rats to exhibit a comparable incidence of SIB. Taken together, the study reveals that repeated administration of GBR induces SIB that is dependent on the integrity of nigrostriatal dopaminergic system and the presence of D1 and/or D2 DA receptors.

PMID:
8535847
DOI:
10.1016/0006-8993(95)00604-o
[Indexed for MEDLINE]

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