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Mamm Genome. 1995 Sep;6(9):636-9.

The role of melanocyte-stimulating hormone (MSH) receptor in bovine coat color determination.

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Department of Animal Science, Agricultural University of Norway, As, Norway.


The melanocyte-stimulating hormone (MSH) receptor has a major function in the regulation of black (eumelanin) versus red (phaeomelanin) pigment synthesis within melanocytes. We report three alleles of the MSH-receptor gene found in cattle. A point mutation in the dominant allele ED gives black coat color, whereas a frameshift mutation, producing a prematurely terminated receptor, in homozygous e/e animals, produces red coat color. The wild-type allele E+ produces a variety of colors, reflecting the possibilities for regulating the normal receptor. Microsatellite analysis, RFLP studies, and coat color information were used to localize the MSH-receptor to bovine Chromosome (Chr) 18.

[Indexed for MEDLINE]

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