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Pediatr Neurol. 1995 Sep;13(2):153-6.

Trihexyphenidyl and isoprinosine in the treatment of subacute sclerosing panencephalitis.

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1
Division of Neurology, São Lucas Hospital, Porto Alegre, Brazil.

Abstract

Six cases of subacute sclerosing panencephalitis (1 stage I, 3 stage II, 2 stage III) were diagnosed at our institution in the last 10 years. Five patients were treated with isoprinosine and the antiepileptic drug valproic acid. Three patients presented with myoclonic seizures refractory to valproic acid and the usual antiepileptic therapy. They received trihexyphenidyl with good results. We suggest the use of trihexyphenidyl in combination with isoprinosine in patients with subacute sclerosing panencephalitis with myoclonic seizures refractory to valproic acid.

PMID:
8534281
DOI:
10.1016/0887-8994(95)00145-6
[Indexed for MEDLINE]

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