Format

Send to

Choose Destination
Trends Genet. 1995 Dec;11(12):513-9.

Polygenic disease: methods for mapping complex disease traits.

Author information

1
Wellcome Trust Centre for Human Genetics, University of Oxford, UK.

Abstract

Improved genotyping technology has made it feasible to use a genetic approach to map genes involved in the etiology of common human diseases. We discuss here recent developments in several different statistical approaches to linkage analysis of these traits, including affected-sib-pair methods, the affected-pedigree-member method, regressive models and linkage-disequilibrium-based approaches. We discuss advantages and disadvantages of the various approaches, as well as factors influencing study design and the ability to detect loci. Statistical methodology in this area is advancing rapidly and will help enable the mapping and cloning of loci involved in susceptibility to common multifactorial diseases.

PMID:
8533170
DOI:
10.1016/s0168-9525(00)89163-5
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center