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Trends Biochem Sci. 1995 Oct;20(10):431-4.

The role of p53 in regulating genomic stability when DNA and RNA synthesis are inhibited.

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Department of Molecular Biology, Cleveland Clinic Foundation, OH 44195, USA.


In addition to its induction by DNA damage, p53 is induced by drugs that starve cells for DNA and RNA precursors, or by inhibitors of DNA or RNA polymerase. In normal cells, the induction of p53 by dNTP starvation serves a protective role, mediating rapid, reversible cell-cycle arrest without DNA damage. In most cell lines, this first line of defense is missing, so that starvation for dNTPs causes DNA to break, thus increasing the probability of genomic instability, chromosome deletions and gene amplification. The mechanism of how p53 is induced remains unclear.

[Indexed for MEDLINE]

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