Send to

Choose Destination
Trends Biochem Sci. 1995 Oct;20(10):416-20.

SOS-regulated proteins in translesion DNA synthesis and mutagenesis.

Author information

Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA.


Studies of Escherichia coli have revealed that most mutagenesis resulting from exposure to UV radiation and various chemicals (SOS mutagenesis) requires the operation of a specialized system involving the UmuD', UmuC, RecA and DNA polymerase III proteins, which allows translesion synthesis to occur on damaged DNA templates. The SOS mutagenesis system is induced by DNA damage and is subject to elaborate regulatory control involving both transcriptional derepression and post-translational activation and inhibition. The implications of the E. coli SOS mutagenesis system for mutagenesis in other organisms are discussed.

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center