Format

Send to

Choose Destination
Immunobiology. 1995 Jul;193(2-4):293-304.

Transcriptional regulation of the human intercellular adhesion molecule-1 gene: a short overview.

Author information

1
Ernst Boehringer Institut, Bender & Co, Vienna, Austria.

Abstract

Human intercellular adhesion molecule-1 (ICAM-1), a transmembrane glycoprotein that functions as a ligand for lymphocyte function-associated antigen-1, plays an important role in mediating cell-cell interactions in inflammatory reactions. It is induced by proinflammatory cytokines such as interleukin-1, tumor necrosis factor-alpha or interferon-gamma, as well as by phorbol esters, retinoic acid and lipopolysaccharide. Furthermore, ICAM-1 is upregulated by interleukin-6, which suggests that it belongs to the family of acute phase response genes. Investigation of the 5'-regulatory region of the human ICAM-1 gene revealed sequence motifs for a variety of transcription factors implicated in transcriptional regulation. This review summarizes the current knowledge of the transcriptional regulation of the human ICAM-1 gene.

PMID:
8530158
DOI:
10.1016/S0171-2985(11)80558-9
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center