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Curr Opin Struct Biol. 1995 Aug;5(4):457-63.

Native-like and structurally characterized designed alpha-helical bundles.

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DuPont Merck Pharmaceutical Company, Wilmington, USA.


A number of coiled coils and alpha-helical bundles have recently been designed, and many have now been structurally characterized by X-ray crystallography. Others have not been as well characterized structurally but exhibit native-like properties in aqueous solution. Both areas of investigation have contributed greatly to our understanding of the nature of specificity in this class of molecules.

[Indexed for MEDLINE]

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