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Bioessays. 1995 Nov;17(11):911-4.

Chromosomes take an active role in spindle assembly.

Author information

1
University of North Carolina, Biology Dept. Chapel Hill 27599-328, USA.

Abstract

The assembly of a bipolar spindle is essential for the accurate segregation of replicated chromosomes during cell division. Do chromosomes rely solely on other cellular components to regulate the assembly of the bipolar spindle or are they masters of their own fate? In the Zhang and Nicklas(1) study reviewed here, micromanipulation techniques and video microscopy were used to demonstrate the different roles that chromosome arms, kinetochores and centrosomes play in bipolar spindle assembly.

PMID:
8526883
DOI:
10.1002/bies.950171102
[Indexed for MEDLINE]

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