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Am J Psychiatry. 1995 Dec;152(12):1812-4.

Lack of efficacy of clozapine monotherapy in refractory obsessive-compulsive disorder.

Author information

1
Department of Psychiatry, Yale University School of Medicine, New Haven, Conn., USA.

Abstract

OBJECTIVE:

The authors assessed the efficacy of clozapine monotherapy for adults with treatment-resistant obsessive-compulsive disorder.

METHOD:

Twelve adults with refractory obsessive-compulsive disorder participated in a 10-week, open-label, systematic trial of clozapine. They were assessed with the Yale-Brown Obsessive Compulsive Scale, the Hamilton Depression Rating Scale, and the global improvement item of the Clinical Global Impression (CGI) scale.

RESULTS:

None of the 10 patients who completed the trial was a responder. No significant change was observed in obsessive-compulsive or depressive symptoms or in scores on the CGI global improvement item.

CONCLUSIONS:

These findings suggest that clozapine monotherapy is not effective for most adult patients with treatment-resistant obsessive-compulsive disorder.

PMID:
8526253
DOI:
10.1176/ajp.152.12.1812
[Indexed for MEDLINE]
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