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Virology. 1995 Dec 1;214(1):289-93.

Dimerization of the human papillomavirus E7 oncoprotein in vivo.

Author information

1
Laboratory of Molecular Virology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.

Abstract

We have used a yeast two-hybrid system to show that human papillomavirus E7 proteins can form oligomeric complexes in vivo. The carboxyl-terminal cysteine-rich metal-binding domain is critical for this activity although amino-terminal sequences also contribute to oligomerization. Our experiments also reveal that E7 possesses an intrinsic transcription activation activity in yeast, which resides in the amino terminus of the protein.

PMID:
8525630
DOI:
10.1006/viro.1995.9926
[Indexed for MEDLINE]
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