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Proc Natl Acad Sci U S A. 1995 Dec 5;92(25):11598-602.

Alternative translation initiation site usage results in two functionally distinct forms of the GATA-1 transcription factor.

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1
Laboratorio Nazionale-Consorzio Interuniversitario Biotecnologie, Trieste, Italy.

Abstract

GATA-1 is a zinc-finger transcription factor that plays a critical role in the normal development of hematopoietic cell lineages. In human and murine erythroid cells a previously undescribed 40-kDa protein is detected with GATA-1-specific antibodies. We show that the 40-kDa GATA-1 (GATA-1s) is produced by the use of an internal AUG initiation codon in the GATA-1 transcript. The GATA-1 proteins share identical binding activity and form heterodimers in erythroleukemic cells but differ in their transactivation potential and in their expression in developing mouse embryos.

PMID:
8524811
PMCID:
PMC40449
[Indexed for MEDLINE]
Free PMC Article
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