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Nature. 1995 Dec 7;378(6557):578-83.

Nucleation of microtubule assembly by a gamma-tubulin-containing ring complex.

Author information

1
Department of Biochemistry and Biophysics, University of California at San Francisco 94143-0448, USA.

Abstract

The highly conserved protein gamma-tubulin is required for microtubule nucleation in vivo. When viewed in the electron microscope, a highly purified gamma-tubulin complex from Xenopus consisting of at least seven different proteins is seen to have an open ring structure. This complex acts as an active microtubule-nucleating unit which can cap the minus ends of microtubules in vitro.

PMID:
8524390
DOI:
10.1038/378578a0
[Indexed for MEDLINE]

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