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J Med Chem. 1995 Dec 8;38(25):4950-2.

1-Phenyl-3-(aminomethyl)pyrroles as potential antipsychotic agents. Synthesis and dopamine receptor binding.

Author information

1
Department of Chemistry, Neurogen Corporation, Branford, Connecticut 06405, USA.

Abstract

A series of 1-phenyl-3-(aminomethyl)pyrroles were prepared in two steps from aniline and their affinities for D2, D3, and D4 dopamine receptor subtypes determined. A 15-fold selectivity for cloned human D4 receptors over cloned African Green monkey D2 receptors was observed with 1-(2-pyridyl)-4-[[3-(1-phenylpyrrolyl)]methyl]piperazine.

PMID:
8523409
DOI:
10.1021/jm00025a013
[Indexed for MEDLINE]

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