Abstract
During chronic infections in cystic fibrosis, persistence of Pseudomonas aeruginosa is associated with conversion into forms that are associated with conversion into forms that are characterized by a mucoid colony morphology, rough lipopolysaccharide and, paradoxically, decreased systemic virulence. The mutations underlying these changes occur in global regulators, such as alternative sigma factors and their accessory elements.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Bacterial Capsules / biosynthesis*
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Base Sequence
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Chronic Disease
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Cystic Fibrosis / complications*
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Genes, Bacterial / physiology*
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Humans
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Lung Diseases / complications
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Lung Diseases / microbiology*
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Molecular Sequence Data
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Mutation / genetics*
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Phenotype
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Pseudomonas Infections / complications
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Pseudomonas Infections / microbiology*
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Pseudomonas aeruginosa / pathogenicity
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Pseudomonas aeruginosa / physiology*
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Transformation, Bacterial / genetics
Associated data
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GENBANK/L41667
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GENBANK/U15180