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Trends Genet. 1993 Apr;9(4):138-41.

The multistep nature of cancer.

Author information

1
Johns Hopkins Oncology Center, Baltimore, MD 21231.

Abstract

Cancer is a distinct type of genetic disease in which not one, but several, mutations are required. Each mutation drives a wave of cellular multiplication associated with gradual increases in tumor size, disorganization and malignancy. Three to six such mutations appear to be required to complete this process.

PMID:
8516849
DOI:
10.1016/0168-9525(93)90209-z
[Indexed for MEDLINE]

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