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Am J Obstet Gynecol. 1977 May 1;128(1):51-9.

Upper genital tract changes associated with exposure in utero to diethylstilbestrol.


Hysterosalpingograms of 60 young women exposed in utero to diethystilbestrol were obtained. In 46 instances, documentation of this exposure was obtained from the mother's chart review or confirmed by the attending physician. In 14 instances, the patients' mothers were sure they had received stilbestrol, but documentation could not be specifically confirmed. Hysterosalpingograms of 23 women being investigated for infertility during the same period that the current study was conducted were also reviewed. In 40 women exposed to stilbestrol, changes in the uterus which differed significantly from those seen in the past in nonexposed individuals were noted. These changes consisted of a 'T-shaped appearance of the uterus,' constricting bands in the uterine cavity, a hypoplastic uterus, and less frequently, intrauterine polypoid defects, synechiae, and in one instance a unicornuate uterus. In 36 of the 40 women gross defects were also noted in the cervix. By comparison, in none of the control subjects were defects noted which could be considered comparable with those seen in the DES-exposed patient.


Hysterosalpingography was employed to study 60 young women who were exposed in utero to diethylstilbestrol (DES). Exposure to DES was documented in 46 cases. 40 subjects exposed to DES displayed a ''T-shaped appearance of the uterus,'' constricting bands in the uterus, hypoplastic uterus, and in some cases, intrauterine polyploid defects, synechiae, and a unicornate uterus. 36 of these women also showed gross defects of the cervix. In contrast, none of the infertile control subjects exhibited defects comparable in degree to those observed in the subjects exposed to DES in utero.

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