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Ophthalmology. 1993 Jun;100(6):966-70.

Immunoblastic B-cell malignant lymphoma involving the orbit and maxillary sinus in a patient with acquired immune deficiency syndrome.

Author information

1
Department of Ophthalmology, Cullen Eye Institute, Baylor College of Medicine, Houston, TX 77030.

Abstract

BACKGROUND:

A 44-year-old man was diagnosed with acquired immune deficiency syndrome (AIDS)-related complex in 1986. Four years later, erythema and swelling of the right lower eyelid and face and a palpable mass along the right inferior orbital rim developed. Computed tomographic scans of the orbits disclosed a mass involving the right superior antrum and inferior orbit. Histopathologic examination and immunohistochemical studies of the tumor were performed.

METHODS:

Immunohistochemical studies were performed on paraffin sections of the neoplasm. Markers used included leukocyte-common antigen and L26 (pan B-cell marker), and MT1, Leu22, polyclonal CD3, UCHL-1, and OPD4 (pan T-cell markers). Additional markers included cytokeratin, HMB-45, lysozyme, S-100 protein, kappa, and lambda.

FINDINGS:

The neoplastic cells were strongly to moderately positive with LCA, L26, MT1, and Leu22. Negative staining was observed with the remaining nine antibodies.

CONCLUSION:

Orbital lymphomas in patients with AIDS have been rarely documented; those few reported cases showed a B-cell phenotype. The authors report an immunoblastic B cell with immunophenotypic coexpression of T-cell markers.

PMID:
8510913
DOI:
10.1016/s0161-6420(93)31547-2
[Indexed for MEDLINE]

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