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J Bacteriol. 1993 Jun;175(12):3887-92.

Transcriptional analysis of the Streptomyces glaucescens tetracenomycin C biosynthesis gene cluster.

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1
School of Pharmacy, University of Wisconsin, Madison 53706.

Abstract

A 12.6-kb DNA fragment from Streptomyces glaucescens GLA.0 containing the 12 genes for tetracenomycin (TCM) C biosynthesis and resistance enabled Streptomyces lividans to produce TCM C. Transcriptional analysis of the tcmPG intergenic region in this cluster established the presence of two divergent promoters. The tcmIc mutation, a T-to-G transversion in the -10 region of the tcmG promoter, decreased promoter activity drastically at the stationary growth stage and time of maximum TCM C accumulation. This promoter may direct the transcription of a tcmGHIJKLMNO operon, while the other promoter is for tcmP.

PMID:
8509340
PMCID:
PMC204805
[Indexed for MEDLINE]
Free PMC Article
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