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Curr Opin Cell Biol. 1993 Apr;5(2):269-73.

The regulatory diversity of the mammalian adenylyl cyclases.

Author information

1
Department of Pharmacology, University of Washington, Seattle 98195.

Abstract

Clones for six mammalian adenylyl cyclases have recently been isolated. One of these enzymes, the type I calmodulin-sensitive adenylyl cyclase, is neurospecific and is implicated in neuroplasticity. We propose that the type I adenylyl cyclase may be important for learning and memory because it allows Ca(2+)-amplified cAMP signals, synergism between Ca2+ and cAMP-activated kinases, and positive feedback regulation of Ca2+ channels by cAMP-dependent protein kinase.

PMID:
8507499
DOI:
10.1016/0955-0674(93)90115-7
[Indexed for MEDLINE]

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