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Curr Opin Genet Dev. 1993 Apr;3(2):246-53.

Regulation of the HNF-1 homeodomain proteins by DCoH.

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Beckman Center for Molecular and Genetic Medicine, Stanford University Medical School, CA 94305.


The pattern of expression of homeodomain proteins often exceeds their apparent domain of activity. Tissue-specific proteins that modulate the in vivo activity of homeodomain proteins have been proposed to account for this functional restriction. The first identified example of such an accessory protein is DCoH, which confers transcriptional activity to the hepatocyte nuclear factor 1 and provides a model of how other accessory factors might modulate the function of homeodomain proteins.

[Indexed for MEDLINE]

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