Cholesterol 7 alpha hydroxylase promoter separated from cyclophilin pseudogene by Alu sequence

Biochim Biophys Acta. 1993 Jun 12;1168(2):239-42. doi: 10.1016/0005-2760(93)90130-2.

Abstract

The promoter for human cholesterol 7-alpha hydroxylase has been cloned and sequenced. In the regions previously described, our sequence agrees well with one report but not with another. At position -469, we find a widespread MaeII polymorphism. At -2636, there is an Alu sequence flanked by runs of adenines. Upstream of the Alu sequence, there is a cyclophilin pseudogene oriented in the opposite direction.

MeSH terms

  • Amino Acid Isomerases / genetics*
  • Base Sequence
  • Carrier Proteins / genetics*
  • Cholesterol 7-alpha-Hydroxylase / genetics*
  • Cloning, Molecular
  • Humans
  • Molecular Sequence Data
  • Peptidylprolyl Isomerase
  • Polymorphism, Genetic
  • Promoter Regions, Genetic*
  • Pseudogenes*
  • Repetitive Sequences, Nucleic Acid*
  • Sequence Alignment

Substances

  • Carrier Proteins
  • Cholesterol 7-alpha-Hydroxylase
  • Amino Acid Isomerases
  • Peptidylprolyl Isomerase

Associated data

  • GENBANK/L04613
  • GENBANK/L04614
  • GENBANK/L04615
  • GENBANK/L04616
  • GENBANK/L07951
  • GENBANK/L10669
  • GENBANK/L17031
  • GENBANK/L17032
  • GENBANK/L17033
  • GENBANK/X61667