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Muscle Nerve. 1993 Jun;16(6):642-7.

Association of IgG anti-GD1a antibody with severe Guillain-Barré syndrome.

Author information

1
Department of Neurology, Niigata University, Japan.

Abstract

We earlier reported cases of 2 patients with severe acute Guillain-Barré syndrome (GBS) associated with high-IgG anti-GD1a antibody titer. We now have investigated the autoantibody against GD1a or GM1 in 37 GBS patients using the enzyme-linked immunosorbent assay and have found a statistically significant association between IgG anti-GD1a antibody and the severity of the disease (need of a respirator for more than 1 month and a poor functional prognosis 3 months after neurologic onset). An autopsy which showed severe GBS associated with IgG anti-GD1a antibody produced the following findings: (1) severe axonal degeneration and segmental demyelination of peripheral nerves; (2) lymphocytic infiltration; and (3) marked central chromatolysis of the lower motoneurons.

PMID:
8502262
DOI:
10.1002/mus.880160610
[Indexed for MEDLINE]

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