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Folia Histochem Cytobiol. 1993;31(1):9-13.

Chloramphenicol, an inhibitor of mitochondrial protein synthesis, inhibits myoblast fusion and myotube differentiation.

Author information

1
Department of Cell Biology, Jan Zurzycki Institute of Molecular Biology, Jagiellonian University, Kraków, Poland.

Abstract

Chloramphenicol (100 micrograms/ml), an inhibitor of mitochondrial protein synthesis, inhibits the fusion of myoblasts isolated from chick embryo pectoral muscle in both, serum supplemented and serum-free culture conditions. This inhibition of myotube formation appeared reversible only in the defined media. Tryptose phosphate broth and nucleosides, when added in the presence of chloramphenicol, were able to restore the cell capacity to proliferate but not to fuse and differentiate.

PMID:
8500631
[Indexed for MEDLINE]

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