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Trends Biochem Sci. 1993 Feb;18(2):48-52.

Nerve growth factor revisited.

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  • 1Department of Biological Chemistry, College of Medicine, University of California, Irvine 92717.


Recent studies on nerve growth factor have revealed important new insights into the structure, function and evolution of this prototypical neurotrophic factor. Some of its features are (1) it has a unique three-dimensional fold that has since been found in two other growth factors, (2) it uses the trk proto-oncogene product, which has a tyrosine kinase, as a receptor and (3) it shares homology with at least three other factors, now collectively called neurotrophins, which have a spectrum of target cells.

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