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J Oral Pathol Med. 1993 Mar;22(3):138-40.

Effect of sialoadenectomy on the carriage of Candida albicans in the mouths of rats.

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Department of Oral Pathology, Faculty of Odontology, Piraciacaba-SP, Brazil.


Xerostomia provoked in rats by surgical removal of the major salivary glands significantly increased oral carriage of Candida albicans. Five weeks after 3 oral inoculations of 10(8) CFU, C. albicans were found in the mouths in 50% of normal animals but after 8 weeks in none. In xerostomic rats, 100% had oral C. albicans after 5 weeks and after 18 weeks, 66.6% still harboured yeasts. Over the whole experimental period the amount of C. albicans was greater in the mouths of sialoadenectomized than in normal rats.

[Indexed for MEDLINE]

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