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J Infect Dis. 1993 May;167(5):1210-2.

Immunogenicity of Haemophilus influenzae type b conjugate vaccine in children with congenital asplenia.

Author information

1
Department of Pediatrics, University of British Columbia, Vancouver, Canada.

Abstract

The immunogenicity of Haemophilus influenzae type b polysaccharide-protein conjugate vaccines in congenitally asplenic children is unknown. The short-term immunogenicity of the H. influenzae type b polysaccharide-diphtheria toxoid conjugate vaccine was therefore assessed in 10 children with congenital asplenia by measuring antipolyribosyl-ribitol phosphate antibody titers. An excellent antibody response was seen in 9 children (mean geometric titer in responders after immunization 44.7 micrograms/mL; range, 2.59-402). The remaining child responded to a booster dose. Further studies are required to assess whether H. influenzae type b conjugate vaccines are immunogenic in infancy in the presence of congenital asplenia.

PMID:
8486956
DOI:
10.1093/infdis/167.5.1210
[Indexed for MEDLINE]

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