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Nature. 1993 May 13;363(6425):133-40.

C. elegans lin-45 raf gene participates in let-60 ras-stimulated vulval differentiation.

Author information

1
Department of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder 80309-0347.

Abstract

Vulval differentiation in Caenorhabditis elegans is controlled by intercellular signalling mediated by a receptor tyrosine kinase and a ras gene product. The lin-45 gene encodes a homologue of the raf family of serine/threonine kinases and is necessary for vulval differentiation. The lin-45 raf gene product appears to act downstream of the ras protein in this pathway. A proto-oncogene-mediated signalling pathway may be a common feature of metazoan development.

PMID:
8483497
DOI:
10.1038/363133a0
[Indexed for MEDLINE]

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