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Ann Intern Med. 1993 Jun 1;118(11):838-43.

The effectiveness of ovarian cancer screening. A decision analysis model.

Author information

1
Medical College of Wisconsin, Milwaukee.

Abstract

OBJECTIVE:

To estimate the effectiveness of ovarian cancer screening with CA 125 and transvaginal sonography.

DESIGN:

Decision analysis was used to examine the no-screen compared with the screen strategy.

SETTING:

Estimates of cancer incidence, survival, and life expectancy were derived from population-based data and clinical series.

SUBJECTS:

A cohort of 40-year-old women of all races and residing in the United States.

INTERVENTIONS:

A one-time screening intervention. The criterion standard for diagnosis of ovarian cancer was evaluation with exploratory laparotomy.

MAIN OUTCOME MEASURE:

Average years of life expectancy gained by women in the screened group.

RESULTS:

Screening for ovarian cancer with a combination of CA 125 and transvaginal sonography increases the average life expectancy in the population by less than 1 day.

CONCLUSIONS:

Given the limited effect on overall life expectancy, it is unlikely that mass screening for ovarian cancer with CA 125 and transvaginal sonography would be an effective health policy.

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PMID:
8480957
[Indexed for MEDLINE]

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