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Trends Biochem Sci. 1993 Mar;18(3):90-5.

Multiple functions of nucleosomes and regulatory factors in transcription.

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Center for Gene Regulation, Pennsylvania State University, University Park 16802.


The in vivo packaging of DNA with histone proteins to form chromatin makes its transcription a difficult process. Biochemical and genetic studies are beginning to reveal mechanistic details of how transcriptional regulatory factors confront at least two hurdles created by nucleosomes, the primary structural unit of chromatin. Regulatory factors must gain access to their respective binding sites and activate the formation of transcription complexes at core promoter elements. Distinct regulatory factors may be specialized to perform these functions.

[Indexed for MEDLINE]

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