Format

Send to

Choose Destination
Trends Biochem Sci. 1993 Mar;18(3):84-9.

A template for the protein kinase family.

Author information

1
Department of Chemistry, University of California, San Diego, La Jolla 92093-0654.

Abstract

The crystal structure of the catalytic subunit of cAMP-dependent protein kinase, complexed with ATP and a 20-residue inhibitor peptide, is reviewed and correlated with chemical and genetic data. The striking convergence of the structure with the biochemistry and genetics provides for the first time a molecular basis for understanding how this enzyme functions, as well as an explanation for the highly conserved residues that are scattered throughout the molecule. Because these residues probably serve a common role in all eukaryotic protein kinases, this first protein kinase structure serves as a general template for the entire family of enzymes.

PMID:
8480367
DOI:
10.1016/0968-0004(93)80001-r
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center