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Trends Biochem Sci. 1993 Mar;18(3):84-9.

A template for the protein kinase family.

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Department of Chemistry, University of California, San Diego, La Jolla 92093-0654.


The crystal structure of the catalytic subunit of cAMP-dependent protein kinase, complexed with ATP and a 20-residue inhibitor peptide, is reviewed and correlated with chemical and genetic data. The striking convergence of the structure with the biochemistry and genetics provides for the first time a molecular basis for understanding how this enzyme functions, as well as an explanation for the highly conserved residues that are scattered throughout the molecule. Because these residues probably serve a common role in all eukaryotic protein kinases, this first protein kinase structure serves as a general template for the entire family of enzymes.

[Indexed for MEDLINE]

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