Low-dose rapamycin potentiates the effects of subtherapeutic doses of cyclosporine to prolong renal allograft survival in the mongrel canine model

Transplantation. 1993 Apr;55(4):947-9.
No abstract available

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Cyclosporine / pharmacology*
  • Cyclosporine / therapeutic use
  • Disease Models, Animal
  • Dogs
  • Dose-Response Relationship, Drug
  • Drug Synergism
  • Drug Therapy, Combination
  • Duodenitis / chemically induced
  • Female
  • Gastritis / chemically induced
  • Graft Survival / drug effects*
  • Kidney Transplantation / immunology*
  • Male
  • Pancreatitis / chemically induced
  • Polyenes / administration & dosage*
  • Polyenes / toxicity
  • Sirolimus
  • Time Factors
  • Transplantation, Homologous / immunology

Substances

  • Polyenes
  • Cyclosporine
  • Sirolimus