Isradipine attenuates the ischemia-induced release of dopamine in the striatum of the rat

Eur J Pharmacol. 1993 Mar 16;233(1):165-8. doi: 10.1016/0014-2999(93)90363-m.

Abstract

We examined the effect of isradipine, a blocker of L-type voltage-sensitive Ca2+ channels (VSCCs), on the ischemia-induced release of dopamine in the rat striatum. Perfusion of 200 micrograms/ml isradipine in the striatum did not alter extracellular dopamine concentrations monitored by microdialysis. However, a marked increase (145-fold) in dopamine level during forebrain ischemia, developed by bilateral carotid artery occlusion, was attenuated significantly by 37% by isradipine whereas the intensity of ischemia, monitored by striatal blood flow, was unchanged. These results suggest that isradipine attenuates the ischemia-induced release of dopamine via blockade of L-type VSCCs on dopaminergic neurons.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 3,4-Dihydroxyphenylacetic Acid / metabolism
  • Animals
  • Blood Gas Analysis
  • Brain Ischemia / metabolism*
  • Cerebrovascular Circulation / drug effects
  • Corpus Striatum / drug effects
  • Corpus Striatum / metabolism*
  • Dialysis
  • Dopamine / metabolism*
  • Hydrogen-Ion Concentration
  • Injections
  • Isradipine / administration & dosage
  • Isradipine / pharmacology*
  • Male
  • Rats
  • Rats, Inbred SHR

Substances

  • 3,4-Dihydroxyphenylacetic Acid
  • Dopamine
  • Isradipine