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Clin Cardiol. 1993 Apr;16(4 Suppl 1):I3-5.

Oxidized LDL and atherogenesis: relation to risk factors for coronary heart disease.

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Center for Human Nutrition, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas 75235-9052.


According to a new theory, a critical step in atherogenesis is oxidation of low-density lipoprotein (LDL) within the arterial wall. Direct data supporting this theory are limited, but indirect evidence suggests that oxidized LDL plays a role in atherogenesis. An important question is whether the LDL-oxidation hypothesis conforms to what is known about other risk factors for coronary heart disease (CHD), such as hypertension, smoking, low high-density lipoprotein (HDL) levels, and diabetes mellitus. Perhaps a unified theory of atherogenesis could be formulated if these risk factors exert their atherogenic actions in part by promoting, facilitating, or permitting the oxidation of LDL.

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