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Histochemistry. 1993 Jan;99(1):37-41.

Carbonic anhydrase isoenzymes II and I are present in the zona glomerulosa cells of the human adrenal gland.

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1
University of Oulu, Department of Anatomy, Finland.

Abstract

Human carbonic anhydrase isoenzymes I and II (HCA I and II) were purified from human erythrocytes by inhibitor affinity chromatography and ion-exchange chromatography. These isoenzymes were then located in the human adrenal gland using specific polyclonal antisera raised in rabbits and specific detection by immunohistochemical techniques. Both HCA II and I were located in the zona glomerulosa cells, although the staining for HCA I was faint. The cells of the zona fasciculata and the zona reticularis failed to stain with either antiserum. Control stainings with preimmune or anti-HCA VI sera were negative. The presence of HCA II and I in the zona glomerulosa cells may be linked to regulation of the biosynthesis or secretion of mineralocorticoids.

PMID:
8468192
[Indexed for MEDLINE]

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