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Immunol Today. 1993 Mar;14(3):111-5.

Proteoglycans on endothelial cells present adhesion-inducing cytokines to leukocytes.

Author information

1
Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.

Abstract

Leukocyte recruitment from the blood circulation into tissue is essential for effective immune responses, and is, consequently, carefully regulated. In this article Yoshiya Tanaka and co-workers describe a model in which proteoglycans on the luminal surface of endothelium capture pro-adhesive cytokines. These cytokines provide the adhesion-inducing signal to particular leukocyte subsets which initiates their transmigration.

PMID:
8466625
DOI:
10.1016/0167-5699(93)90209-4
[Indexed for MEDLINE]

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