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Nature. 1993 Apr 8;362(6420):511-7.

Largest subunit of Drosophila transcription factor IID directs assembly of a complex containing TBP and a coactivator.

Author information

1
Howard Hughes Medical Institute, Department of Molecular and Cell Biology, University of California, Berkeley 94720.

Abstract

The TFIID complex consists of the TATA-binding protein (TBP) and associated factors (TAFs) serving to mediate transcriptional activation by promoter-specific regulators. Here we report the cloning of Drosophila TAFII250 and the assembly of a partial complex containing recombinant TBP, TAFII110 and the C-terminal domain of TAFII250. This triple complex supports Sp1 activation and reveals specific interactions between TAFII250, TBP and TAFII110.

PMID:
8464492
DOI:
10.1038/362511a0
[Indexed for MEDLINE]

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