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Infect Dis Clin North Am. 1993 Mar;7(1):21-36.

Adherence events in the pathogenesis of infective endocarditis.

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Pediatric Critical Care Service, Mayo Clinic, Rochester, Minnesota.


Infective endocarditis begins with adherence of microorganisms to cardiac tissues. These tissues have often been previously damaged, creating a thrombotic lesion consisting of platelets and fibrin. Circulating microorganisms localize to this lesion. The tissue specificity of endocarditis likely results from interactions between cell-surface determinants on the endocardium, platelet, and microorganism. Interference with these binding events may offer a means of modifying the course of the infection.

[Indexed for MEDLINE]

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