Format

Send to

Choose Destination
See comment in PubMed Commons below
Neuron. 1993 Mar;10(3):345-57.

Guidance and topographic stabilization of nasal chick retinal axons on target-derived components in vitro.

Author information

1
Max-Planck-Institut für Entwicklungsbiologie, Tübingen, Germany.

Abstract

We studied mechanisms underlying the generation of topographic order within the developing chick retinotectal connection by combining the recently introduced stripe assay with a novel membrane protein fractionation technique. Our experiments show a preference of temporal and nasal retinal fibers for growing on cell membranes prepared from their proper target area. In addition, membrane preparations from posterior tectum were found to prolong substantially the survival of nasal neurites in vitro. We conclude that tropic as well as trophic interactions contribute to the generation of topographic maps during embryogenesis, in our case to the homing of nasal axons within the posterior tectum.

PMID:
8461131
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center