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FEBS Lett. 1993 Apr 5;320(2):140-4.

Ca2+ binding of latent transforming growth factor-beta 1 binding protein.

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1
Ludwig Institute for Cancer Research, Uppsala, Sweden.

Abstract

Latent transforming growth factor-beta 1 binding protein (LTBP) is a constituent of the latent high molecular weight complex of TGF-beta 1 in human platelets. In the present communication, we show that LTBP binds Ca2+ in its free form as well as in the latent TGF-beta 1 complex. The binding of Ca2+ induces a structural change which protects the molecule against proteolysis and changes its elution position when analyzed by anion exchange chromatography. The in vitro activation of TGF-beta 1 is not influenced by the presence of Ca2+. The possible significance of Ca2+ binding of LTBP is discussed.

PMID:
8458430
DOI:
10.1016/0014-5793(93)80079-a
[Indexed for MEDLINE]
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