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Arthritis Rheum. 1993 Apr;36(4):465-72.

HLA class II alleles and heterogeneity of juvenile rheumatoid arthritis. DRB1*0101 may define a novel subset of the disease.

Author information

1
Institute of Transplantation Immunology, Oslo Sanitetsforenings Rheumatism Hospital, University of Oslo, Norway.

Abstract

OBJECTIVE:

To examine the distribution of HLA class II alleles in clinically distinct juvenile rheumatoid arthritis (JRA) subsets.

METHODS:

We typed 298 patients and 181 controls for HLA-DRB1, DQA1, DQB1, and DPB1 alleles using polymerase chain reaction and oligonucleotide probe techniques.

RESULTS:

Each JRA subset was characterized by a distinct distribution of HLA class II alleles. For the persistently pauciarticular and rheumatoid factor-negative polyarticular JRA subsets, certain combinations of DRB1 and DPB1 alleles were characteristic. In patients without antinuclear antibodies and chronic iridocyclitis, there was an increase of DRB1*0101/02 and DQA1*0101.

CONCLUSION:

Findings of HLA typing support clinical subdivisions of the disease and suggest the existence of a novel DRB1*0101/02 and DQA1*0101 associated disease subset.

PMID:
8457222
DOI:
10.1002/art.1780360406
[Indexed for MEDLINE]

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